不良研究所

不良研究所 pharmacy researchers link olive oil to preventing cancer, Alzheimer鈥檚

Published May 25, 2017

By Vladimir Jakovljevic (不良研究所 Office of Public Information)

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In the summer of 1965, a team of researchers at the University of Florida formulated a carbohydrate-electrolyte beverage to help their football players cope with heat and heat-related illnesses. Since the university football team is the Florida Gators, they named the breakthrough thirst-quenching beverage Gatorade.

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Today, two researchers at the University of Louisiana Monroe are developing a product which they believe could have an even greater benefit 鈥� prevention of two of humanity鈥檚 most devastating illnesses, cancer and Alzheimer鈥檚 disease.

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Since 2009, Professor Khalid El Sayed, Ph.D., and Associate Professor Amal Kaddoumi, Ph. D., of the Basic Pharmaceutical Sciences Department of the 不良研究所 School of Pharmacy, have worked on a project to develop an olive oil-based food supplement to help prevent cancer and Alzheimer鈥檚 disease.

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The El Sayed-Kaddoumi project is titled 鈥�Novel extra-virgin olive oil-based functional food for cancer and Alzheimer鈥檚 disease prevention.鈥� It focuses on extracting and testing the effects of oleocanthal, one of the most active compounds of olive oil.

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鈥淥ur recent studies showed that oleocanthal selectively suppressed several human breast cancer cell lines,鈥� El Sayed said. 鈥淚n addition to its cancer preventive and control activity, oleocanthal has also demonstrated an anti-Alzheimer鈥檚 disease activity and we also found evidence for its potential to reduce the risk of Alzheimer鈥檚 disease.鈥�

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Kaddoumi said she is confident their oleocanthal-based product could prevent cancer and Alzheimer鈥檚 if taken early enough.

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鈥淲e are very optimistic in terms of prevention because the mice experiments we conducted show that the earlier you give this compound, the more efficient the outcome will be,鈥� Kaddoumi said.

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Next step: developing an oral delivery method

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The experiments with mice were conducted by injecting them with extracted oleocanthal. Now the scientists are developing a way for humans to take oleocanthal by mouth. This could be an instant powder beverage or a capsule.

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The oral form would be tested on mice to see if it produces the same preventive effects as the injectable extract.

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If that testing is successful, the human trials could begin.

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鈥淚n other words, we have to prove the same effect on humans,鈥� El Sayed said. 鈥淲e are optimistic that we will have the product out on the market. However, clinical trials are necessary to prove that we can apply it to humans, and those are often very expensive and time-consuming.鈥�

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La. Board of Regents backs research

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Kaddoumi and El Sayed recently partnered with Segue Therapeutics, owned by Dr. James Cardelli, a retired 30-year LSU Health Science Center-Shreveport faculty member, who will provide $22,500 over a three-year period for the project.

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鈥淪egue Therapeutics considers this a project that can potentially be commercialized and have a very good outcome,鈥� El Sayed said. 鈥淭his collaboration is very important because it allows us to secure more funds.鈥�

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Due to their collaboration with Segue Therapeutics, the researchers have recently secured something much bigger, a $225,000 award from the . It covers three years beginning July 1.

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After reviewing 28 research proposals requesting a total of $2,489,579 in funding, the Board of Regents categorized seven proposals, including 不良研究所鈥檚, as 鈥淧riority One: Highly Meritorious Proposals Recommended for Funding.鈥�

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, ahead of other institutes in Louisiana, including LSU, University of Louisiana Lafayette and Tulane Medical School.

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The board described El Sayed, Kaddoumi and Cardelli as 鈥渢hree investigators with extensive and distinguished publication records who form an excellent research group with evidence of productivity in the field.鈥�

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鈥淭his award is a great accomplishment and it will help us develop, test and promote our olive oil-based product, especially because we filed a patent on novel isolation and therapeutic application methods,鈥� El Sayed said.

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Kaddoumi and El Sayed, in collaboration with Cardelli, hope three years from now to have their product available as a dietary food supplement capsule and an instant dry powder drink.

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The financial potential of the olive oil product is clearly enormous. To put it in perspective, today Gatorade has 75 percent of the sports drink market in the United States. Worldwide, the company topped $3.3 billion in sales in 2016.

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However, the prospect of preventing cancer and Alzheimer鈥檚 is priceless.

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